I was so anxious about this trip probably because I am overtired, as I slept poorly last night. But tomorrow it’s actually happening, I am leaving work at 3 PM.
First thing I noted was gas was cheap – $3.02 a gallon but avocado’s were expensive. Thanks Trump. Only needed about $70 in groceries but I think I was pretty much good on camping supplies and just needed a partial restock of my pantry before heading north. Got $40 from the bank so I had some money to get bacon from For the Love of Bacon on my way up to the Adirondacks. Going to grab a few pallets if I have enough room, though my truck is kind of packed with the camping gear plus the burnables I plan to burn that accumulated over the winter – lots of wrappers and paper for fire starting and burning. Would have brought more, but the stuff that isn’t confidential I guess the recycling man can get.
Going to be off the grid for a few days, which is great though it’s pretty remote country. But I’ll be fine, I always am. Going to rain a lot on Friday night into Saturday but Friday and Sunday look pretty good for the bulk of the day, and Saturday I can maybe smoke some pot and do some reading and fishing in the rain on the East Branch. Brining the mountain bike and I’ll ride on Sunday around the Perkins Clearing, do some fishing and then I was thinking I would drive back to Rotterdam Junction by 4 or 5 PM and ride the Erie Canal Trail until dusk and then come home and unpack. Get groceries and do my laundry on Monday night after work. I am so excited to be heading back up to the remote wilderness again!
The spot on the map you end up in Eastern NY when you are using unprojected coordinates in Eastern NY and forget to cast as a float. I wonder how many people end up at Glenhurst Stock Farm when their GPS or mapping program goes nutty.
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Colibactin is produced by bacteria commonly found in the digestive system, including certain types of E. coli. About 20% of healthy people—and even some 31% of babies—have colibactin-producing E. coli in their guts, previous studies estimate.67
The toxin is known to damage DNA, and previous studies have suggested that colibactin-related mutations contribute to some cases of colorectal cancer.8
Dziubańska-Kusibab PJ, Berger H, Battistini F, et al. Colibactin DNA-damage signature indicates mutational impact in colorectal cancer. Nat Med. 2020;26(7):1063-1069. doi:10.1038/s41591-020-0908-2 But Ludmil Alexandrov, PhD, a professor of cellular and molecular medicine at the University of California, San Diego and senior author of the new study, didn’t set out to research colibactin specifically.
Originally, his team wanted to understand why people in different countries develop colorectal cancer at different rates. They genetically analyzed almost 1,000 colorectal cancer samples from people living in 11 countries to compare and contrast them.
“We did find some results which were country-specific,” Alexandrov said. “But actually, the thing that we found most exciting was this colibactin result.”
Alexandrov’s team found that DNA mutations associated with colibactin were 3.3 times more common in cancers diagnosed before age 40, compared to those diagnosed after age 70. They estimated that colibactin exposures likely happened early in study participants’ lives—probably before their 10th birthdays.
The results suggest that colibactin exposure could “put children on a trajectory for developing colorectal cancer 20 or 30 years earlier [than normal]—so instead of getting it at the age of 60 or 70, they’re getting it at the age of 30 or 40,” Alexandrov explained.