Wayne County is a county located in the U.S. state of Pennsylvania. As of 2010, the population was 52,822. Its county seat is Honesdale.

The terrain of the county is varied. In the wider northern half, it is rugged along its borders; with higher hills found along the western border, lower ones in the east near the river and a wide plain in the middle. The southern portion tends to be swampier.

The highest elevation in the county, 2,656 feet (809.5 m), is the summit of Mount Ararat in Preston Township, near Orson. Two other summits at the north end of the same ridge also exceed 2,640 feet (804.6 m) elevation. The lowest point is along the Delaware River at the Pike County line, approximately 680 feet (207.2 m).

Most of the county is drained by the Delaware River (which separates it from New York,) except for small western areas drained by the Starrucca Creek and the Lackawanna River into the Susquehanna River.