Back when I was in college, I used to drive back and forth between Plattsburgh and Albany a lot. I used to try a variety of routes, some more indirect then others, to see the scenery, especially when I had extra time to burn in the afternoon.

1) Via the Adirondack Northway.

The most direct and quick way is via the Adirondack Northway (I-87) all the way up.

2) Via 9N Through Ticonderoga – West Side of Lake George.

This way is really slow as you wind your way up and over Tongue Mountain, and through all the little resort towns along the west side of Lake George.

3) Via NY 22 – East Side of Lake George.

This route is moderately fast. There is some spectular secenry along NY 22 as you head from Whitehall to Ticonderoga, with sweeping views of Lake Champlain.

4) Via Lake Champlain Bridge and Burlington.

I quite often would take this route over the old Lake Champlain Bridge when I wanted to visit Burlington. The old bridge was beautiful, as is the landscape after you cross into Vermont. Burlington is an amazingly nice city too.

5) Via NY 22A and Burlington.

I used to come back via Burlington some times, by taking VT 22A through the dairy country of southern Vermont. The land is pretty flat, and VT 22A, but there are still some amazing views of the Adirondack Mountains along this route.