I was a fast-food worker. Let me tell you about burnout. – Vox
I was a fast-food worker. Let me tell you about burnout. – Vox
So to test your new antidepressant, you need an efficient method of making a lot of rats exhibit anhedonia — that is, making them lose interest in things they used to enjoy, like sugar. How do you think you’d do that? It turns out you don’t need to traumatize them. The most reliable protocol is “chronic mild stress.”
There are many methods of making the lives of experimental animals mildly but chronically miserable — a cage floor that administers random electric shocks; a deep swimming pool with no way to rest or climb out; a stronger “intruder” introduced into the same cage. One neuroscientist actually nicknamed his apparatus the Pit of Despair. But they’re all variations on the same theme: remove all predictability and control from the animal’s life. Then take notes as they gradually lose interest in being alive.

